We source higher strength colostrum, with a minimum IgG content of 30%. Most colostrums are around 10-15% IgG.
If Echinacea is a soldier fighting to keep the body’s immune system healthy, then Colostrum is a complete army. In fact, it has 37 immune factors and a dozen growth factors that help repair skin, bones, muscle and connective tissue to help keep our bodies young and offer superb immune support.
In stock (can be backordered)
We source higher strength colostrum, with a minimum IgG content of 30%. Most colostrums are around 10-15% IgG.
If Echinacea is a soldier fighting to keep the body’s immune system healthy, then Colostrum is a complete army. In fact, it has 37 immune factors and a dozen growth factors that help repair skin, bones, muscle and connective tissue to help keep our bodies young. A full list is found below.
What is Colostrum?
Colostrum is arguably nature’s most effective immune system booster, featured in Susan Clark’s ‘What Really Works in Natural Medicine’. The ‘first milk’ produced by dairy cows in the days immediately after calving, it has a high concentration of proteins with antibodies. Colostrum is completely transferable to humans hence we can enjoy the significant health benefits from this natural and potent protector.
What does it do?
Rigorous scientific testing of Colostrum in the US and the UK has found it to:
What can it help?
Its composition is so potent and varied that it can be used to help a wide range of conditions. In particular it can:
The bioactive factors found in bovine colostrum provide enhancement of nutrient absorption, growth stimulation, defence against enteric pathogens, and modulation of the immune system. This group includes immunoglobulins, growth factors, anti-inflammatory factors, and anti-microbial factors.
Immunoglobulins are well-known parts of the immune system, and they constitute an important part of the adaptive immune system as they neutralize enteric pathogens, such as bacteria, microbes and viruses (Janeway, 2001). The immunoglobulins in bovine colostrum come in five different varieties:
The immunoglobulins constitute the largest group of immune components in colostrum (Kehoe et al., 2007). The dominant immunoglobulin in bovine colostrum is IgG, which makes up 85-90% of the total immunoglobulin content, with IgG1 constitutes up to 80-90% of the total IgG content (Larson et al., 1980; Barrington et al., 1997). The immunoglobulins IgG2, IgM and IgA are present at lower concentrations.
The contents in bovine colostrum belong to both the innate and the adaptive immune system. The innate immune system is the first line of defense and protects against enteric infectious pathogens by detecting and eliminating them through a complex interaction between cellular and molecular processes. Later, the adaptive immune system takes over by a response mediated through T and B cells relying on memory to quickly respond to threats to which it has previously been disposed (Stelwagen et al., 2009).
Immunoglobulins are the main component in the adaptive immune system, but bovine colostrum contains a wide range of other immune-regulating factors that are important. Trypsin inhibitor is a protease that protects IgGs and other bioactive proteins against degradation in the intestine. A wide variety of components linked to the innate immune system have been identified in bovine colostrum, such as cytokines, oligosaccharides, gangliosides, proteins and peptides and many more (Stelwagen et al., 2009).
Cytokines are small hormone-like proteins that are involved in cell signaling, pathogen recognition and immune cell recruitment in the immune system. They regulate the development and expression of a broad array of immune responses against a variety of enteric pathogens, as they are the critical determinants of which types of immune cells that are needed to regulate and participate in both innate and adaptive immune responses. As such, they act both in local environments, but also in a systemic manner. Cytokines are also themselves directly antimicrobial (Banyer et al., 2000; Mookherjee and Hancock, 2007). Cytokines include interleukins (e.g., IL-1β, IL-2, IL-6, IL-7, IL-8, IL-10, IL-11, IL-12, IL-17), tumor necrosis factor (TNF-α), interferon (INF-γ) and other compounds that contribute to control of infections and inflammations (Wheeler et al., 2007; Rathe et al., 2014).
Bioactive oligosaccharides are also found in bovine colostrum, and they may also help protect against pathogens and promote growth of beneficial bacteria flora in the gut lumen, as they act as competitive inhibitors for the binding sites on the epithelial surfaces of the gut (Gopal & Gill, 2000; Godden, 2008; Rathe et al., 2014).
Gangliosides are polar lipids found in the milk fat globule membrane and are involved in several functions. They are also involved in several biological procedures such as neural development, pathogen binding and activation of the immune system (Lee et al., 2013).
Bovine colostrum contains several different growth factors that especially stimulate growth and development, such as insulin-like growth factors, epidermal growth factors, transforming growth factors, and platelet-derived growth factors (Thapa, 2005). They control cell division and cell differentiation and thus promote growth and development. Some growth factors are especially important for the gastrointestinal tract, as they are involved in both tissue growth and epithelial cell modifications, which ultimately closes the intestine and makes it a formidable barrier for alien bacteria, microbes and pathogens (Xu, 1996; Elfstrand et al., 2002).
The most abundant and best describes growth factors are the insulin growth factors (IGF-I and IGF-II). These proteins promote cellular growth. They are heat and acid stable and can withstand the degradative conditions of the gastrointestinal tract, and their effect may thus both be local or mediating systemic eﬀects (Pakkanen & Aalto, 1997; Rathe et al., 2014). The homology between human and bovine insulin growth factors is 100%, indicating similar physiological effects and pointing to bovine colostrum as efficient human diet supplementation (Chatterton et al., 2013).
Transforming growth factors (TGF-α and TGF-βs) are also present in bovine colostrum. They are included in maintaining epithelial functional and integrity, and in the regulation of the immune system by induction of regulatory T cells, and are also anti-inflammatory. TGF-βs are important for the tissue repair and stimulation of restitution, formation of bone and cartilage, and control of the immune system. (Pakkanen & Aalto, 1997; Playford et al., 2000). TGF-βs in bovine and human colostrum are 100% structurally similar (Chatterton et al., 2013). Transforming growth factor-α is a peptide involved in maintaining epithelial function and integrity in the gut (Playford et al., 2000; Rathe et al., 2014).
Epidermal growth factors (EGFs) are present in far smaller amounts than insulin-like growth factors. They stimulate production of epithelial cells and promote wound healing, especially in the gut (Dvorak et al., 2003). They are only minimally degraded by heat and gastric acid and can thus maintain their biological activity until they reach the gut (Britton et al., 1989). TGF-α could actually be included in this groups also as it is involved in maintaining and developing epithelial function and integrity (Pakkanen & Aalto, 1997). The milk fat globule epidermal factors-8 (MFG-E8) have recently been reported to be significantly anti-inflammatory, and is present in bovine colostrum in high concentrations, ensuring adequate levels in the intestine (Chatterton et al., 2013).
Platelet-derived growth factors (PGFs) in a bioactive factor that triggers cell division in fibroblasts, the cells responsible for synthesizing the structural framework for tissue, and are thus important for wound healing (Pakkanen & Aalto, 1997; Playford et al., 2000).
Other growth factors found in bovine colostrum are betacellulin, and vascular endothelial growth factors that promote formation of new blood vessels and cell division and thus participate in wound healing (Playford et al., 2000).
Bovine colostrum contains several bioactive factors with antimicrobial activity that helps protect against pathogens. Specific peptides and proteins belonging to the innate immune system has also been reported to likely be antibacterial, antifungal, or antiviral products, or their combination (Christoffersen, 2006; Fernandes, 2006).
Much of the antimicrobial activity of colostrum is due to the immunoglobulins, although colostrum also contains other antimicrobial factors. Lactoferrin and lactoperoxidase are two antibacterial immune factors belonging to the innate immune system (Pakkanen & Aalto, 1997). Lactoferrin is a glycoprotein with iron-binding, lipopolysaccharide-binding, immune-modulating, antibacterial and growth-regulating effects. Lactoperoxidase is an enzyme that inhibits bacterial metabolism and it is toxic to a range of Gram-positive and Gram-negative bacteria (Seifu et al., 2005). Lysozyme is an antibacterial enzyme also found in the innate immune system that is also toxic to Gram-negative bacteria causing cell death by lysis and to Gram-positive bacteria by inhibiting growth (Clare et al., 2003; Wheeler et al., 2007). The presence of lactoferrin enhances the antibacterial activity of lysozyme against the bacteria Escherichia coli (Pakkanen & Aalto, 1997).
Vitamins are antioxidants and help improving the immunity of different cell types. Colostrum contains both fat-soluble (A, D, and E) and water-soluble (B, and C) vitamins. The vitamins in the complex of vitamin B are important in several metabolic pathways, such as energy production from nutrients and hormone synthesis (Pereira, 2014), while vitamin C is essential for the production of collagen in the connective tissue.
The amount of fat-soluble vitamins depend on the milk fat content. Vitamin A is especially important for growth, development, and immunity; vitamin D promotes uptake of calcium and phosphorus in the gut and have immune-regulating activities; vitamin E is a group of compounds protecting the body cells from degradation by (Pereira, 2014). The tocopherols belong to the vitamin E-group and are thus antioxidant.
Mean concentrations of selected minerals in bovine colostrum have been determined to be (Kehoe et al., 2007):
Children and colostrum
The return to school marks the major shift in every child’s life-year. New friends, new learning, new teachers, a host of changes and new experiences. It is also a role of changes in season, climate, and daily schedule. Perhaps due to all of these reasons – and the major one of increased contact with lots of other children – this is the time of year when children are also most susceptible to catching whatever may be going around the school and community.
Take one capsule the first day, two the second, and so on, adding one each day until you reach eight a day. Then take eight a day for a week, and then drop down to four a day which is the normal maintenance dose. Each dose should be taken with a large glass of tepid water on an empty stomach. Children aged 6-12 years may take one or two capsules per day.
Immunecare Colostrum comes in bottles of 120 vegetarian capsules, which is a normal month’s supply. We use only 100% pure colostrum from New Zealand and Australia, from pasture fed and free ranging cows. Our pure Colostrum is guaranteed hormone, pesticide and antibiotic free, and we only source ethically collected supplies where the calf is not deprived or harmed in any way. Both New Zealand and Australia are recognised as being BSE free countries by the WHO.
Although Immunecare Colostrum may be taken by those suffering from lactose intolerance with no ill effects, we do not recommend that you take colostrum if you suffer from a clinically diagnosed dairy allergy. The amount of lactose in colostrum is very low (163 mg in two capsules compared to 13,000 mg in one 8-oz glass of milk).
120 Vegetarian Capsules (480mg Pure Colostrum).